Hepatitis is associated with our lives, and it is closely related to our lives. It always threatens our physical and mental health. But it's different kinds of communication ways, let us impossible to guard against. How much do you know about its type? Next, let me interpret the type for you. As follows:
At present, there are at least 5 kinds of hepatitis viruses known as hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV),
Hepatitis D virus (HDV) and hepatitis B virus (HEV).
Hepatitis A virus (HAV)
Type a viral hepatitis, referred to as hepatitis A, is an acute infectious disease caused by hepatitis A virus (HAV). The clinical manifestations of acute onset, chills, fever, anorexia, nausea, fatigue, hepatomegaly and abnormal liver function. Some cases of jaundice, asymptomatic infection cases are more common, generally does not change to chronic and pathogenic carrying status
Hepatitis B virus (HBV)
Hepatitis B virus (HBV) belongs to the liver DNA virus family. The complete HBV granules were first detected by Dane in the sera of patients with hepatitis B virus infection, so it is called Dane granule. Dane particles are spherical, 42nm in diameter, and have double capsid. The coat of the virus, equivalent to the general virus envelope, surface antigen HBV (HBsAg) is embedded in the membrane lipid bilayer, the internal structure is the core of a higher electron density, is 20 surface of cubic symmetry, a diameter of about 27nm, the surface is underwear shell virus, underwear shell protein the antigenicity of HBV core antigen (HbcAg). The enzyme or detergent after exposed with different antigenicity of e antigen (HBeAg). HbeAg is secreted in the body and is present in the serum, whereas HbeAg is found only in the nucleus of the infected liver and is rarely present in serum circulation. The inner part of the HBV core structure contains the viral DNA and DNA polymerase. DNA is an incomplete circular double stranded, which has a single stranded, single stranded region length ranging from the virus, but not more than half of the full-length gene. Long strands of viral DNA are negative strands. While the shorter strand is the positive strand, and the virion has a special DNA polymerase, which has both the reverse transcriptase function of DNA and the function of DNA synthesis by using RNA as template.
Hepatitis C virus (HCV)
1, acute hepatitis C: adult acute hepatitis C is relatively mild, most of the acute jaundice hepatitis, ALT increased mainly, a small number of acute jaundice hepatitis, jaundice is mild or moderate rise. Nausea, loss of appetite, weakness of the body, yellow urine and yellow eyes can occur. Hepatitis C virus infection rarely results in liver failure. Under natural conditions, of which only 15% were able to spontaneously clear HCV cure, in antiviral therapy intervention, 85% patients developed chronic hepatitis C; children with acute hepatitis C virus infection, 50% spontaneous clearance of HCV.
2, chronic hepatitis C: mild symptoms, common symptoms of hepatitis, such as fatigue, appetite, abdominal distension and so on. Can also be without any symptoms of consciousness. Laboratory ALT fluctuated repeatedly, and HCVRNA remained positive. Liver function in patients with chronic HCV infection has been normal for 1/3, HCV and HCVRNA have been persistently positive, liver biopsy can show chronic hepatitis, and even cirrhosis can be found.
3, hepatitis C cirrhosis: HCV infection in 20-30 years, 10%~20% patients can develop cirrhosis of the liver, 1%~5% patients will lead to hepatocellular carcinoma death. In the event of decompensated cirrhosis, the incidence of jaundice, ascites, variceal bleeding, hepatic encephalopathy, and so on, decreases dramatically.
Hepatitis D virus (HDV)
Hepatitis B virus is a defective virus, its biological cycle depends on the completion of the hepatitis B virus, hepatitis D therefore cannot exist alone, must be in the presence of HBV infection and can cause diseases, therefore, there are hepatitis B and hepatitis B with overlapping infection or infection at the form. Mode of transmission is similar to hepatitis B, China's high rate of infection in the southwest region, HDV HBsAg positive infection rate of more than 3% human beings are susceptibility to HDV.
Hepatitis E virus (HEV)
HEV is a single stranded RNA virus was spherical, diameter 27 ~ 34nm non enveloped nucleocapsid is twenty surface of cubic symmetry. It is not in vitro tissue culture, but chimpanzee, cynomolgus monkey, Ganges RIver monkey, African green monkey, to marmoset is sensitive to HEV, can be used for virus isolation. HEV is stable in alkaline environment, with magnesium and manganese ions in the presence of integrity, high sensitivity to heat, and inactivation by boiling. HEV gene 3 'end leader 7.6kb, poly A, there are three open reading frames (ORF), ORF1 is located in the 5' end (about 2KB) is a non structural protein gene, sequence dependent RNA polymerase containing RNA, ORF2 in the 3 'end (about 2KB) is the main part of the structural protein, can nuclear capsid protein encoding, ORF3 and ORF1 and ORF2 overlap (full length 369bp), as well as virus structural protein gene of virus specific antigen encoding immune response.
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